Why Did Pfizer Choose the Bivalent “Booster” over the “Monovalent” Booster?
First, a Comment on this Post.
Normally I would just comment but he wants to get paid for the privilege so I will just comment by way of posting here
You can read the whole thing, but here are his main points
Within 30 days of taking your Pfizer [bivalent] booster, you lost 44% of your first level (antibody) immune response against the original Omicron variant BA1.
And
Looking at the table above we see that adding 30 ug of the original Pfizer vaccine against Wuhan Hu1 (that everybody has taken for the 1st and 2nd shots and the boosters up until September 2022), to 30ug of the new Omicron BA4/5 vaccine component decreases its effectiveness after one month from 19.6x to 10.9x a reduction of 44%
And
Furthermore, 30 days after your Pfizer booster shot (30 ug of vaccine against Wuhan Hu1) you would have had 44% fewer antibodies against Omicron than you had before you took the booster according to Pfizer’s own figures.
And
Within 30 days of taking your Pfizer booster, you lost 44% of your first level (antibody) immune response against the original Omicron variant BA1. That is why the infection rates in the vaccinated were so much worse than the infection rates in the unvaccinated for Omicron.
And
Pfizer’s bivalent versus monovalent trial results shows that one shot (30ug) of the old vaccine destroys 44% of your Covid19 antibodies in 30 days.
They measured abs 1 month after the booster. The abs were significantly above the baseline (pre-booster). They did not report a decline over time in the study. Although its effectiveness to BA1 is diminished compared to the BNT162b2 (Wuhan ) shot.
However it increases abs to BA 4/5 , so the tradeoff is justified as BA4/5 will be the dominant variant.
The bigger question is why not just use the monovalent BA 4/5 since it produced more neutralizing abs to everything. Perhaps someone who has a patent to BNT162b2 mRNA would lose patent rights for the new Booster if their mRNA was not included in the new shot? I’ll let you figure it out.
Thats all. Carry on.