VA STUDY- COVID is Worse in Those Reinfected
Up to 10% reinfected within 1 year
Interesting paper out
Acute and postacute sequelae associated with SARS-CoV-2 reinfection
https://www.nature.com/articles/s41591-022-02051-3.pdf
There were 443,588 cohort participants with no SARS-CoV-2 reinfection (only a single SARS-CoV-2 infection) and 40,947 participants who had SARS-CoV-2 reinfection (two or more infections)
5,334,729 participants with no record of positive SARS-CoV-2 infection were in the noninfected control group.
Among those who had reinfection, 37,997 (92.8%) people had two infections, 2,572 (6.3%) people had three infections and 378 (0.9%) people had four or more infections.
The median distribution of time between the first and second infection was 191 d (interquartile range (IQR) = 127–330) and between the second and third was 158 d (IQR = 115–228).
Compared to those with no reinfection, those who had reinfection exhibited an increased risk of all-cause mortality (HR = 2.17, 95% CI = 1.93–2.45) and excess burden of all-cause mortality estimated at 19.33 (95% CI = 15.34–23.82) per 1,000 persons at 6 months; all burden estimates represent excess burden and are given per 1,000 persons at 6 months
People with a reinfection also had an increased risk of hospitalization (HR = 3.32, 95% CI = 3.13–3.51; a burden of 100.19 (92.53–108.25))
Furthermore, impaired health as a consequence of the first infection might result in increased risk of adverse health consequences upon reinfection.
Our results expand this evidence base and show that in people who get reinfected, reinfection (compared to no reinfection) further increases risk in both the acute and postacute phases and that this was evident even among fully vaccinated people, suggesting that even combined (a hybrid of) natural immunity (from previous infection) and vaccine-induced immunity does not abrogate the risk of adverse health effects after reinfection.
Although the Veterans Affairs population which consists of those who are mostly older and male may not be representative of the general population, our cohorts included 10.3% women, which amounted to 589,573 participants, and 12% were under 38.8 years of age (the median age of the US population in 2021), which amounted to 680,358 participants. Subgroup analyses were not conducted by age, sex and race.
Not mentioned but in the supplementary data, all cause mortality higher in vaccinated
Sars -Cov-2 infection vs uninfected control
For some reason they don’t look at All Cause Mortality for this comparison.
Anyways, so if you get infected you are more likely to end up in the hospital over the next year than if you were not infected
There are two possibilities, those who get infected are unhealthier to begin with than those that do not, or Sars-Cov-2 messes you up your health for some period of time after recovery. Some combination of the 2 is possible as well
Conclusion- For those who get infected by Sars-Cov-2, about 10% are likely to be reinfected within 1 year and they may experience worse outcomes.
This may because their first bout of COVID caused a general deterioration in their overall health (which may include their immune system) or those who are reinfected experience Immune Enhancement or Antibody Dependent Enhancement (ADE)
Its unknown whether these results are the same (or worse) with the latest Omicron Variants, and if reinfection after a year will also result in a worse outcome than the initial infection
Of course, for those who don’t believe in Viruses you don’t need to bother your little brains about that. Its all good.
That said, viruses like people who provide a fertile terrain for them to replicate. They are the unhealthy people or those who are genetically susceptible. Most people have little to worry about, especially younger people, unless this cycle of infection and reinfections over many years causes a general degradation in population health even among healthy people, especially those who are harming their health with these spike producing mRNA concoctions.
We may be on the cusp of a drastic reduction in life expectancy which will surely save the Social Security and Medicare problem for the GOP. Maybe thats why they don’t seem so eager to address the cause of Excess Deaths or the idea Sars-Cov-2 was a biological weapon designed by non-chinese actors (China was a partner) living and working a stones throw from DC
Thx for pointing to the supplementary data, and discussion.