OAS1 (Rs10774671), The Interferon Stimulated Gene SARS-CoV-2 Hates
And Pfizer and Fauci don't want you to know about it
OAS 1 is an Interferon Stimulated Gene that helps create an anti-viral state . You have to mount a immune response that produces INF-I to turn it on .
A study has shown 2′-5′-oligoadenylate synthetase 1 (OAS1) consistently inhibited SARS-CoV-2 . Endogenous OAS1 makes a substantial contribution to the antiviral state by recognizing short stretches of double-stranded RNA (dsRNA) and activating RNase L.
OAS1 (Rs10774671) was associated with less severe COVID-19. People with at least one allele with a G at OAS1 (Rs10774671) could express a prenylated form of OAS1 (p46), which was necessary for OAS1 to initiate a block to SARS-CoV-2. Individuals without C-terminal prenylation could not block to SARS-CoV-2.
Prenylation targeted OAS1 to perinuclear structures rich in viral dsRNA, whereas non-prenylated OAS1 was diffusely localized and unable to initiate a detectable block to SARS-CoV-2 replication.
So the gene that produces OAS1 recognizes bits of the SARS CoV2 genome. In humans, the letter G at Rs10774671 in OAS1 can blunt severe COVID19
https://www.science.org/doi/10.1126/science.abj3624
39% of the global population have G at Rs10774671. Results from the American, Asian and European continents are similar to those reported globally. Mexico is 31%. Interestingly, for the African continent, the G allele is in 64% of the population
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310884/
This may very well be part of the reason Africa has fared very well with COVID
As mentioned, OAS 1 is an Interferon Stimulated Gene . So you have to mount a immune response that produces INF-I to turn it on .Toll Line Receptors 7/8 of the innate immune system do that, but they are down regulated after vaccination.
That seems likely to affect production of OAS1 thus muting the protective effect to limit severe COVID19
https://www.medrxiv.org/content/10.1101/2021.05.03.21256520v1.full-text